Endothelial Cells adhered on a three-dimensional matrix. This image shows that the cell morphology adapts to the architecture of the substratum following its contours. Matrix in green, Cell nuclei in blue, Cytoskeleton in red
Endothelial Cell in contact with a contoured surface follows its architecture. The Cytoskeleton (red) perfectly overlays the lines of the scaffolding architecture (grey).
Portray of the scaffolding architecture (green) covered by endothelial cells (cytoskeleton in red, nuclei in blue)
Ring of Cells: Endothelial cells in a three-dimensional matrix follow the contour of the substratum. In this case the matrix has a mesh-type architecture and the cells create rings by avoiding the mesh pores.
Endothelial Cells adapts to the underlying architecture by “bending” or “wrapping to” according to the specific strut dimensions. (Matrix in green, Cytoskeleton in red, Nuclei in blue)
Endothelial Cells on a flat two-dimensional substratum have a completely different morphology, dictated this time by the absence of three-dimensional architecture. Cells appear homogenous and mono-dimensional.
Cytocouture mood board is composed of inspirational images from the world of metabolic Japanese architecture, microscopic endothelial cells, the unisex garments by Rad Hourani, and textures and structures that remind us of the connection between living tissue and the textiles we use to protect our bodies and display our identity.
Cytocouture design concept it’s based on Dr. Laura Indolfi’s endothelial cells research. When these cells are growing they adapt and follow the shapes of the scaffold like structure that they are resting on and according to that shape they have specific behaviors and release different factors. The goal of this research is to repair damaged blood vessels by providing customized therapy. To learn more about the research please click on the link below for an explanatory video.